HIV CDC

 

Study finds reservoir of hidden HIV bigger than once thought

In fact it was reported as being 60-times greater!

http://www.foxnews.com/health/2013/10/24/major-setback-for-aids-cure-study-finds-reservoir-hidden-hiv-bigger-than-once

See full article:

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure, Cell, 24 Oct 2013; vol 155" pp 540-551

http://www.cell.com/abstract/S0092-8674(13)01157-4

Highlights

  • A total of 1.7% of noninduced HIV-1 proviruses have intact genomes and LTR function
  • Reconstructed intact noninduced proviruses are replication competent
  • They are integrated into transcription units and have no CpG methylation in the LTR
  • The size of the latent reservoir for HIV-1 may be underestimated by 60-fold