Study finds reservoir of hidden HIV bigger than once thought
In fact it was reported as being 60-times greater!
See full article:
Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure, Cell, 24 Oct 2013; vol 155" pp 540-551
- A total of 1.7% of noninduced HIV-1 proviruses have intact genomes and LTR function
- Reconstructed intact noninduced proviruses are replication competent
- They are integrated into transcription units and have no CpG methylation in the LTR
- The size of the latent reservoir for HIV-1 may be underestimated by 60-fold